CLINICALLY PROVEN - Zegerid OTC is clinically proven to treat frequent heartburnTHE ONLY OTC PPI WITH TWO ACTIVE INGREDIENTS: Omeprazole provides powerful heartburn relief. Plus, Sodium Bicarbonate ensures your body can absorb it properly.JUST ONE PILL A DAY - Zegerid OTC proton pump inhibitor medication treats frequent heartburn.24 HOURS / ZERO HEARTBURNUse as directed for 14 days for treating frequent heartburn. As with all PPIs, may take 1-4 days for full effect, although some people might get complete relief within 24 hours.